The interaction provides a useful theoretical laboratory to learn about nuclear physics from lattice QCD. As one-pion exchange does not contribute to the potential, the long-distance behavior is dominated by the same physics that provides the intermediate-range attraction between two nucleons. In the heavy-quark limit the force can be unambiguously measured on the lattice. We computed the two-pion box and crossed-box diagrams that provide the leading long-distance contributions to the potential in QCD and in partially-quenched QCD.