Our understanding of nuclear parity violation is limited by our present inability to compute hadronic matrix elements of the parity-violating four-quark operators that arise in the low-energy effective theory of the weak interaction. Further, a consistent picture at the hadronic level is yet to emerge from experimental measurements due to nuclear uncertainties. We motivate lattice QCD studies of the parity-violating pion-nucleon coupling constant and extend flavor-conserving hadronic parity-violation from QCD to partially-quenched QCD. The parity-violating pion-nucleon coupling and the anapole form factor (and moment) of the proton are computed to one-loop order in the partially-quenched chiral expansion. For the parity-violating pion-nucleon interaction, we include the contributions from total derivative operators necessary to match the kinematics that will be used in lattice simulations.